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The Impact of Maternal Levothyroxine Treatment on the Neurodevelopment of Offspring Born to Mothers with Thyroid Dysfunction, Asystematic Review

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Year: 2019
COI code: COBGY15_204
Paper Language: English

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Authors The Impact of Maternal Levothyroxine Treatment on the Neurodevelopment of Offspring Born to Mothers with Thyroid Dysfunction, Asystematic Review

  Sima Nazarpour - Department of Midwifery, Varamin-Pishva Branch, Islamic Azad University, Tehran, Iran / Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  Fahimeh Ramezani Tehrani - Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  Fereidoun Azizi - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract:

Introduction: The thyroid hormones have an important effect on the development of central nervous system before and after birth. Several studies have evaluated the association between maternal thyroid dysfunction during pregnancy and neurocognitive development in offsprings. The important role of maternal thyroid hormones in all stages of the brain development in children is undeniable; deespite that, there is still insufficient evidence on the beneficiary effect of thelevothyroxine treatment in pregnant women with thyroid dysfunctions interms of neurodevelopmental outcomes of their offsprings. The present systematic review was conducted to evaluate the effect of treatment with levothyroxine in pregnant women with thyroid dysfunctions on neurocognitive development in their offsprings.Methods: In this systematic review, the PubMed[including Medline], Web of Science, Wiley, Google Scholar, Science Direct and Scopus databases were searched with appropriate keywords foridentifying and retrieving all English articles published up to March 2018 on the effects of maternal levothyroxine treatment on the neurocognitive development of offspring born to mothers with thyroid dysfunction. The search was performed based on the following keywords:( Levothyroxine OR LT4 OR L-thyroxine OR treatment )AND ( maternal OR pregnancy ) AND ( development OR neurodevelopment ) AND ( offspring OR children ).This study used a series of randomized clinical trials, cohort, case-control studies and case report. Of the 343 related articles in the initial search, 9 eligible studies were finally evaluated.Results: From 9 studies in this field, seven studies showed that administration of levothyroxine in mothers with thyroid dysfunctions had no significant effect on children s cognitive function or other neurodevelopment indicators; only a case report and a study on 13 pregnant women and their children showed that treatment improved the neurocognetive indicators in their offsprings.Conclusions: Current systematic review revealed that treatment with levothyroxine in pregnant women with thyroid dysfunctions has no significant beneficiary effect on neurodevelopment of their offsprings.

Keywords:

Thyroid dysfunction, hypothyroidism, Pregnancy, neurodevelopment, offspring, Levothyroxine

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Nazarpour, Sima; Fahimeh Ramezani Tehrani & Fereidoun Azizi, 2019, The Impact of Maternal Levothyroxine Treatment on the Neurodevelopment of Offspring Born to Mothers with Thyroid Dysfunction, Asystematic Review, 15th International Congress of Women and Obstetrics of Iran, تهران, انجمن متخصصان زنان و مامايي ايران, https://www.civilica.com/Paper-COBGY15-COBGY15_204.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Nazarpour, Sima; Fahimeh Ramezani Tehrani & Fereidoun Azizi, 2019)
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Type: Azad University
Paper No.: 1700
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