The Effect of Sufficient and Insufficient Vitamin E in Treatment of Infertile PCOS Patients

Backgrounds: vitamin E has multiple functions in humans and animals and its antioxidant effect was concluded in cancer therapy, high-risk pregnancy and male infertility. several investigators have demonstrated the benefits of dietary supplementation with vitamin E on fertility in different animal species. The aim of this study is to assess the effect of sufficient and insufficient levels of vitamin E on treatment of infertile PCOS women.Material and Method: in this clinical trial, 144 PCOS infertile patients referred to Dr.rasekh clinic, jahrom,Iran that randomly divided in two groups (groups with sufficient and insufficient levels). Each of these two groups was randomly divided into case and control groups (36 participants in each group). Usual drug regimen of PCOS started for all groups (Metformin and dydrogestrone).Case groups received vitamin E supplemention as an add-on their treatment. Data collection performed via questionnaires by midwives and statistical analysis by SPSS 21.Result: There was a significant relationship between follicular size and use of vitamin E (P <0.05). Increased endometrial thickness and reduced BMI detected in using vitamin E group. The overall pregnancy rate was twenty women(66.7%) which related to the using vitamin E groups.Conclusion: vitamin E has a positive effect on treatment of PCOS patients. Although response to the treatment is better in patients with insufficient vitamin E levels, prescription of this vitamin in patients with sufficient vitamin E level is also effective. According to rare side effects related to this vitamin, its low cost and low toxicity, we recommend to add daily use of vitamin E to drug regimen of infertile PCOS patients.

Keywords:

infertility , Vitamin E , pregnancy rate Main source of funding , private funding by Dr. Athar Rasekhjahromi