A Comparative Study of Single Dose Versus 3 Days Regime of Ampicillin Ccephalosporin and Nitrofurantoin in Treatment of Cystitis in Pregnancy Reffered to Imama Reza Hospital

Backgrounds: Urinary tract infection is the most common bacterial infection that occurs in 2-10% of pregnancies, and causes 30% of mothers of acute pyelonephritis. The timely start of appropriate antibiotics is of particular importance. The aim of this study is to compare single-dose and three-day treatment regimens of ampicillin, cephalosporin and nitrofurantoin in treating cystitis in pregnant women in Imam Reza Hospital in 2016-2018.Material and Method: This study is an interventional clinical trial study. The population of this study was pregnant mothers with diagnosis of pregnancy cystitis referring to Imam Reza Hospital during 2016-2018. 1 gravidity women, aged 35-20 years with no history of systemic diseases and certain medications, and gestational age of 20 weeks, singleton pregnancy with symptoms of cystitis and patients who tested UA And UC have been given in Imam Reza Hospital laboratory and bacteriuria and pyuria have been reported to them, entered the study. Patients were divided into three treatment groups: Ampicillin, Cephalosporin and Nitrofurantoin. In each treatment group, 82 subjects were divided into two subgroups of 41 patients receiving single dose and 3-day antibiotic treatment. Data were recorded in the checklist and analyzed using spss-16 statistics software.Result: The rate of recovery and response to treatment in the cephalexin group (68.29%) was higher than the other two groups (ampicillin (52.43%) and nitrofurantoin (60.9%)) (P = 0.065). The three-day treatment in the ampicillin group (P=0.032) and nitrofurantoin(P= 0.884) was significantly more effective in improving the patients than the single dose of the two drugs. The most common cystic microorganism in our study is E. coli.Conclusion: Cephalexin is more effective than ampicillin and nitrofurantoin in the treatment of pregnancy cystitis