First natural infection report of Nesokia indica with Leishmania infantum in Damghan city, northern Iran

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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DCME02_024

تاریخ نمایه سازی: 19 آذر 1398

Abstract:

Background: Zoonotic Cutaneous Leishmaniasis (ZCL) is a parasitic disease caused by Leishmania species. Several species of rodents are potential reservoir hosts of ZCL and zoonotic visceral leishmaniasis in different parts of Iran.Objectives: The aim of this study was to determine the leishmanial infection of rodents in Damghan city during 2015.Materials and Methods: Totally 100 rodents of three species (Nesokia indica (95), Mus musculus (3), and Microtus socialis (2)) were caught alive. Their tissues were examined using parasitological and PCR assays.Results: A total of 71 (71%) of examined rodents were microscopy positive for Leishman bodies. The highest rate of infection (72.6%; 69/95) was observed in Nesokia indica. The microscopic findings revealed that 42% of their ear samples were positive. 12% of them with negative ear result were positive in liver. Furthermore, 39% (16 out of 41) of microscopy positive samples of N. indica were shown positive by PCR assay, of which, 15 were identified as L. major (13 of ear and 2 of spleen tissue samples) and one of spleen samples was identified as L. infantum.Conclusion: Current study confirmed the first report of N. indica natural infection to L. infantum. More ecological and epidemiological studies are needed to understand the role of this rodent as reservoir host of L. infantum

Authors

Behrad Pourmohammadi

Associat Professor, Department of Parasitology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran/Department of Public Health, School of Health, Semnan University of Medical Sciences, Semnan, Iran

Sadegh Mohammadi-Azni

Assistant Professor, Damghan Health Center, Semnan University of Medical Sciences, Semnan, Iran

Mohsen Kalantari

Assistant Professor, Research Center for Health Sciences, Institute of Health, Department of Medical Entomology and Vector Control, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran