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Evaluation of pretreatment with Cetrotide in an antagonist protocol for patients with PCOS undergoing IVF/ICSI cycles: a randomized clinical trial

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Year: 2019
COI code: DTOGIMED03_053
Paper Language: English

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Authors Evaluation of pretreatment with Cetrotide in an antagonist protocol for patients with PCOS undergoing IVF/ICSI cycles: a randomized clinical trial

Ramesh Baradaran Bagheri - عضو هیات علمى دانشگاه البرز
  Maryam Eftekhar - عضو هیات علمى دانشگاه یزد
  Robabe Hosseinisadat - عضوهیات علمى دانشگاه کرمان
Nosrat Neghab - فلوشیپ نابارورى اهواز

Abstract:

Background and Aim : This study aimed to evaluate the effect of three days of GnRH antagonistpretreatment on the preg- nancy outcomes of women with polycystic ovarian syn- drome (PCOS) on GnRHantagonist protocols for IVF/ICSI.Methods : Fifty women with PCOS in the control group received conventional antagonist protocols,starting on day 2 of the cycle. In the pretreatment group (n=38), a GnRH antagonist was administered fromday 2 of the menstrual cycle for three days.Results : Controlled ovarian stimulation (COS) duration and gonadotropin dosages were similar in bothgroups. The number of metaphase II (MII) oocytes, 2PN oocytes, embryos, along with implantation andclinical pregnancy rates, were higher in the pretreatment group when com- pared with controls, althoughthe increment was not sig- nificant (p value ≥0.05). The chemical pregnancy rate was significantly higherin the pretreatment group. The rate of OHSS was significantly lower in the pretreatment than in the controlgroup.Conclusion : Women with PCOS offered early follicular phase GnRH antagonist pretreatment for threeconsecu- tive days had significantly fewer cases of OHSS and higher chemical pregnancy rates. There weretrends toward great- er numbers of MII oocytes, 2PN oocytes, and embryos, and higher clinical pregnancyrates in the pretreatment group.

Keywords:

assisted reproductive technology, gonado- tropins, polycystic ovarian syndrome

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COI code: DTOGIMED03_053

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Baradaran Bagheri, Ramesh; Maryam Eftekhar; Robabe Hosseinisadat & Nosrat Neghab, 2019, Evaluation of pretreatment with Cetrotide in an antagonist protocol for patients with PCOS undergoing IVF/ICSI cycles: a randomized clinical trial, 3rd debatable topics on obstetrics gynecology & infertility, تهران, دانشگاه علوم پزشكي و خدمات بهداشتي و درماني شهيد بهشتي, https://www.civilica.com/Paper-DTOGIMED03-DTOGIMED03_053.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Baradaran Bagheri, Ramesh; Maryam Eftekhar; Robabe Hosseinisadat & Nosrat Neghab, 2019)
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