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Effect of myo-inositol supplementation on ICSI outcomes among poor ovarian responder patients: a randomized controlled trial

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Year: 2019
COI code: DTOGIMED03_067
Paper Language: English

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Authors Effect of myo-inositol supplementation on ICSI outcomes among poor ovarian responder patients: a randomized controlled trial

  Tayebeh Hashemi Arani - Department of Obstetrics and Gynecology, Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran- IVF center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Leila Nazari - Department of Obstetrics and Gynecology, Preventative Gynecology Research Center, Shahid Beheshti University ofMedical Sciences, Tehran, Iran
  Saghar Salehpour - IVF center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  Sedigheh Hosseini - IVF center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  Nasrin Sharkhiz - IVF center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  Elham Azizi - IVF center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran- Department of Biology and Anatomical Sciences, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract:

Background and Aim : This study was evaluated the use of myo-inositol supplementation for improvingreproductive outcomes in poor responders undergoing intracytoplasmic sperm injection (ICSI).Methods : One hundred and twelve poor responder patients were included in this study and randomlycategorized into two groups using a permuted block randomization method. Group A was 56 patients whoreceived myo-inositol (4 gr) and folic acid (400 μg) daily from one month before starting ICSI cyclecontinuing until the ovulation triggering day. Group B was 56 patients consuming only folic acid (400 μg)daily for the same period. The outcome measures were number of retrieved oocytes, embryo quality,Ovarian Sensitivity Index (OSI: number of oocytes retrieved/total Gonadotropins units × 1000),fertilization, implantation, and ongoing pregnancy rates.Results : No significant difference was observed between the two groups regarding the total dose ofgonadotropin used, OSI, and the number of total retrieved and mature oocytes. Grad A embryos andfertilization rate were significantly increased in group A. Implantation and pregnancy rates did not showstatistically insignificant changes.Conclusion : Treatment of poor responders with myo-inositol from one month before starting ICSI cyclecontinuing until hCG trigger could improve fertilization rate and embryo quality, and may enhancecumulative pregnancy rate among poor responders.

Keywords:

Myo-inositol; intracytoplasmic sperm injection; embryo quality; fertilization; reproductive outcomes

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Hashemi Arani, Tayebeh; Leila Nazari; Saghar Salehpour; Sedigheh Hosseini; Nasrin Sharkhiz & Elham Azizi, 2019, Effect of myo-inositol supplementation on ICSI outcomes among poor ovarian responder patients: a randomized controlled trial, 3rd debatable topics on obstetrics gynecology & infertility, تهران, دانشگاه علوم پزشكي و خدمات بهداشتي و درماني شهيد بهشتي, https://www.civilica.com/Paper-DTOGIMED03-DTOGIMED03_067.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Hashemi Arani, Tayebeh; Leila Nazari; Saghar Salehpour; Sedigheh Hosseini; Nasrin Sharkhiz & Elham Azizi, 2019)
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