Effect of myo-inositol supplementation on ICSI outcomes among poor ovarian responder patients: a randomized controlled trial

Background and Aim : This study was evaluated the use of myo-inositol supplementation for improvingreproductive outcomes in poor responders undergoing intracytoplasmic sperm injection (ICSI).Methods : One hundred and twelve poor responder patients were included in this study and randomlycategorized into two groups using a permuted block randomization method. Group A was 56 patients whoreceived myo-inositol (4 gr) and folic acid (400 μg) daily from one month before starting ICSI cyclecontinuing until the ovulation triggering day. Group B was 56 patients consuming only folic acid (400 μg)daily for the same period. The outcome measures were number of retrieved oocytes, embryo quality,Ovarian Sensitivity Index (OSI: number of oocytes retrieved/total Gonadotropins units × 1000),fertilization, implantation, and ongoing pregnancy rates.Results : No significant difference was observed between the two groups regarding the total dose ofgonadotropin used, OSI, and the number of total retrieved and mature oocytes. Grad A embryos andfertilization rate were significantly increased in group A. Implantation and pregnancy rates did not showstatistically insignificant changes.Conclusion : Treatment of poor responders with myo-inositol from one month before starting ICSI cyclecontinuing until hCG trigger could improve fertilization rate and embryo quality, and may enhancecumulative pregnancy rate among poor responders.

Keywords:

Myo-inositol , intracytoplasmic sperm injection , embryo quality , fertilization , reproductive outcomes