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Analgesic effect of preoperative intravenous administration of paracetamol on post-cesarean pain: A randomized clinical trial

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Year: 2019
COI code: DTOGIMED03_070
Paper Language: English

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Authors Analgesic effect of preoperative intravenous administration of paracetamol on post-cesarean pain: A randomized clinical trial

  Sakineh Mirzaei Khalili Abadi - Department of Obstetrics and Gynecology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  Seyyed Hamid Pakzad Moghadam - Department of Anesthesiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  Masoud Pourparizi - Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  Reza Goujani - Department of Epidemiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  Tayebeh Mirzaei Khalilabadi - Department of Medical Surgical Nursing, School of Nursing and Midwifery, Rafsanjan University of MedicalSciences, Rafsanjan, Iran
  Ali Ravari - Department of Medical Surgical Nursing, School of Nursing and Midwifery, Rafsanjan University of MedicalSciences, Rafsanjan, Iran

Abstract:

Background and Aim : Pain control after every surgery, especially cesarean is highly important, andphysicians are striving to discover pain control methods using the least amount of opioid and Paracetamolis a non-opioid analgesic with few complications. The present study was aimed to investigate the analgesiceffect of preoperative intravenous administration of paracetamol on post-cesarean pain.Methods : This randomized double-blind clinical trial was conducted on 240 pregnant women under spinalanesthesia who were candidate for elective cesarean. The patients’ weight, height, age and body mass index(BMI) were recorded, and patients were randomly divided into two equal groups (n=120). In the first group,10 mg/kg paracetamol in 100cc normal saline (paracetamol group) and in the second group 100cc normalsaline (control group) administered 15 minutes before surgery intravenously. Blood pressure, pulse rate,chills and nausea were recorded during and 1 hour after surgery, and pain visual analogue scale (VAS) andneed for additional analgesic were recorded 1, 2, 4, 6, 12 and 24 hours after surgery.Results : No significant difference was found between the two groups in frequency of chills and nausea(p> 0.05). Mean pethidine consumed was lower in paracetamol group than control group but notsignificantly. Systolic blood pressure of both groups during surgery and one hour after surgery did not showa significant difference, but diastolic blood pressure was significantly lower in paracetamol group 15minutes (p=0.046) and 60 minutes after surgery (p=0.042) than control group. The mean scores of painwere significantly lower in paracetamol group than control group 6 hours (0.008) and 24 hours (p=0.038)after surgery.Conclusion : Within the limitations of the current study, preoperative intravenous administration ofparacetamol significantly reduced post-cesarean pain within 24 hours.

Keywords:

Cesarean Section, Pain, Paracetamol, Pethidine

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COI code: DTOGIMED03_070

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Mirzaei Khalili Abadi, Sakineh; Seyyed Hamid Pakzad Moghadam; Masoud Pourparizi; Reza Goujani; Tayebeh Mirzaei Khalilabadi & Ali Ravari, 2019, Analgesic effect of preoperative intravenous administration of paracetamol on post-cesarean pain: A randomized clinical trial, 3rd debatable topics on obstetrics gynecology & infertility, تهران, دانشگاه علوم پزشكي و خدمات بهداشتي و درماني شهيد بهشتي, https://www.civilica.com/Paper-DTOGIMED03-DTOGIMED03_070.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Mirzaei Khalili Abadi, Sakineh; Seyyed Hamid Pakzad Moghadam; Masoud Pourparizi; Reza Goujani; Tayebeh Mirzaei Khalilabadi & Ali Ravari, 2019)
Second and more: (Mirzaei Khalili Abadi; Pakzad Moghadam; Pourparizi; Goujani; Mirzaei Khalilabadi & Ravari, 2019)
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Paper No.: 282
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