The effect of vitamin D status on ovarian reserve markers in Infertile Women

Background and Aim : Vitamin D deficiency and infertility are two important health problems in Iran.Some studies suggest that vitamin D may influence on Anti-Müllerian hormone (AMH) and antral folliclecount (AFC) as the markers of ovarian reserve . The present study aimed to investigate the impact of vitaminD on AMH serum concentrations /AFC.Methods : Two hundred and eighty seven infertile women who referred to IVF Unit of an academicHospital, between July and December 2017, were included in this study. The demographic characteristicsof the participants, as well as the serum levels of vitamin D, AMH, and ultrasonic examination of AFCwere recorded.Results : Finally, 287 infertile women were included in the analysis. The mean ± SD of patients’ age was29.95 ± 4.73 years. Median AMH and vitamin D levels were 3.20 and 22.82 ng/ml. considering the cut offlevel of 20 ng/ml, 58.7% were vitamin D deficient. Regression analysis showed no association betweenAMH and vitamin D levels (P-value=0.161), even after adjusting for baseline variables (P-value=0.182).Conclusion : The present cross-sectional study showed no significant association between serum levels ofvitamin D and AMH or AFC in infertile women, even after adjusting for confounders.

Keywords:

Anti-Müllerian Hormone , Infertility , Vitamin D Deficiency , Ovarian Follicle