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Evaluation of Reproductive and Pregnancy Health in Women with Multiple Sclerosis

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Year: 2019
COI code: DTOGIMED03_169
Paper Language: English

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Authors Evaluation of Reproductive and Pregnancy Health in Women with Multiple Sclerosis

  Fatemeh Mokhtari - Instructor, Department of Midwifery, School of Nursing and Midwifery, Isfahan University of Medical Sciences,Isfahan, Iran
  Mahboubeh Valiani - PhD of Neurosciences, Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  Freshteh Ashtari - Neurologist, Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


Background and Aim : Multiple sclerosis (MS) is a chronic disease of the central nervous System (CNS).It is more prevalent in women than men. Typical age of onset in the third or fourth decades. Most womenwith MS are diagnosed during their reproductive ages. Therefore, the aim of this study was evaluation ofreproductive and pregnancy health in women with multiple sclerosis.Methods : A retrospective descriptive-analytical study was conducted on 110 women suffering from MSwith a history of pregnancy in Isfahan, Iran in 2018. The subjects had become pregnant within the recentdecade and were selected via random sampling. After receiving their consent, they completed a researcherconstructedquestionnaire by telephone. The questionnaire consisted of three parts: demographicinformation, MS and its symptoms and its treatment, and the third part was related to the fertility profileand the history of pregnancy associated with MS. Data were analyzed by SPSS software version 16 usingChi-square, ANOVA and t-test.Results : The mean age of women with MS in this study was 32.4 years. Most of the subjects studied weremarried (98.2%), had undergraduate and graduate education (51.8%), and of the ordinary social classes(86.4%). The most common primary symptom of the disease in this population was blurred vision (42.7%).81.5% of the patients suffered from the recurrent and declining kind of the disease. In this population, theaverage number of pregnancies was 1.61, the number of deliveries was 1.35, the number of abortions was0.24, the history of ectopic pregnancy was 0.01, the number of alive children was 1.36 and the number ofdead children was 0.01. Most of them had no history of infertility (95.4%). The average time of the last MSattack before the pregnancy was 21.36 months. The most commonly used drug before pregnancy was Sinox(43.4%). Most of the subjects discontinued the medication after planning for pregnancy (97.3%), of which88.1% had no recurrence of the disease during pregnancy. 86.2% of pregnant women did not suffer fromMS attacks. Fatigue (24.5%) was the most common symptom exacerbated during pregnancy. MS symptomsimproved in 55.0% of subjects in the second trimester.Conclusion : MS had no effect on the pregnancy status, such as the number of abortions, ectopic pregnancy,the number of alive and dead children, the state of infertility, and the duration of pregnancy. Therefore, MSdoes not have a negative effect on pregnancy. Also, the symptoms of the disease are improved duringpregnancy with respect to pre-pregnancy and postpartum. The symptoms of the disease are improved duringpregnancy (especially in the second trimester). Therefore, pregnancy has a protective role against MS.


Multiple Sclerosis, Reproductive, Pregnancy, Health

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COI code: DTOGIMED03_169

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Mokhtari, Fatemeh; Mahboubeh Valiani & Freshteh Ashtari, 2019, Evaluation of Reproductive and Pregnancy Health in Women with Multiple Sclerosis, 3rd debatable topics on obstetrics gynecology & infertility, تهران, دانشگاه علوم پزشكي و خدمات بهداشتي و درماني شهيد بهشتي, the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Mokhtari, Fatemeh; Mahboubeh Valiani & Freshteh Ashtari, 2019)
Second and more: (Mokhtari; Valiani & Ashtari, 2019)
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The University/Research Center Information:
Type: Medical University
Paper No.: 3154
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