COMPARISON OF THE EFFECT OF PULMICORT AND SYSTEMIC CORTICOSTEROID ON THE TREATMENT OF PATIENTS WITH ACUTE OBSTRUCTIVE PULMONARY ATTACK REFERRING TO THE EMERGENCY DEPARTMENT

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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EMERGENCYMED14_026

تاریخ نمایه سازی: 26 بهمن 1398

Abstract:

Background and Aim : The aim of this study was to compare the effect of pulmicort and systemiccorticosteroids on the treatment of patients with acute obstructive pulmonary attack (AOPA) bycontrolling confounding factors (age and sex)Methods : This study was a double-blind clinical trial performed on 72 patients with AOPA inBesat Hospital, Tehran, Iran from 20 March 2016 to 20 March 2017. Patients were randomlyassigned into two treatment groups of nebulized pulmicort (budesonide) or systemiccorticosteroids using prednisolone 50 mg or hydrocortisone 200 mg. To test the main hypothesisof the research, logistic regression analyzes were performed while Chi-square and Fisher exacttests were used to tests the sub-hypotheses of the study in SPSS 21.Results : The odds of recovery in patients who received pulmicort was 6.68 times higher than thesystemic corticosteroids treatment group (Odds ratio (OR) = 6.68, P-value = 0.003). The odds ofrecovery in women was 11.48 times higher than men (OR = 11.48, P-value = 0.000). 0.94 odds ofrecovery in older aged patients compared with lower ages showed that the chance of remissionreduces with aging. (OR = 0.94, P-value = 0.002). According to 2 independent sample t-test, thedifference in pt recovery on the basis of age was significant only in the patient who receivedpulmicortConclusion : Based on the results of this study, pulmicort was more effective than systemiccorticosteroid in the treatment of patients with AOPA regardless of their gender

Keywords:

Acute obstructive pulmonary attack , Pulmicort , Systemic corticosteroid

Authors

Seyed Zia Hejripor Rafsanjani

Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran

Saeed Shiralizadeh

Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran

Masoud Shahabian

Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran

Gholamhosein Bagheri

Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran