COMPARISON OF KETAMINE, PROPOFOL/FENTANYL, AND PROPOFOL/KETAMINE FOR REDUCTION OF SHOULDER DISLOCATION BASED ON BISPECTRAL INDEX SYSTEM IN EMERGENCY DEPARTMENT: A RANDOMIZED, THREE GROUPS, DOUBLE BLIND CLINICAL TRIAL
Publish place: 14th iranian annual congress of emergency medicine
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
EMERGENCYMED14_053
تاریخ نمایه سازی: 26 بهمن 1398
Abstract:
Background and Aim : Procedural sedation and analgesia (PSA) is one of the most importanttechniques in the emergency department (ED) that it have several protocols. The purpose of thisstudy was the comparison of various PSA protocols, including propofol/fentanyl,propofol/ketamine, and ketamine, based on the bispectral index system (BIS) and other criticalitems in adults with anterior shoulder dislocation (ASD) in the ED.Methods : This randomized three groups double-blinded clinical trial was conducted on 150patients with ASD in Besat General Hospital in Tehran, Iran. The sample size was considered 50individuals in each group with the administration of propofol/fentanyl (group A),propofol/ketamine (ketofol; group B), and ketamine (group C).. Before PSA, the sensor of BISmonitor was attached to the patient, and several items were compared, including the side effectsand duration of sedation, as well as BIS number before PSA and 1-5 min following that.Results : The BIS values at the 1st, 2nd, 3rd, 4th, and 5th min after PSA were not different in thethree groups. The comparison between the three groups regarding the patients’ satisfaction showedthat there was a significant difference between them (P=0.02), which was higher in the ketofolgroup. The comparison of side effects, induction time, procedure time, sedation time, and recoverytime showed no difference between the three groups (P≥0.05).Conclusion : The investigation of PSA using Propofol-Ketamine, Ketamine, andpropofol/fentanyl showed the similar frequency ofBIS valuesand adverse respiratory events. Theuse of propofol/fentanyl was associated with a slightly higher incidence of hypotension. Moreover, the frequency of patients’ satisfaction was higher among the subjects in group B, compared tothose in the other groups.
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Authors
Maryam Massaeli
Assistant Professor, Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran
Soheil Nasouhi
Assistant Professor, Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran
Masoud Shahabian
Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran
Afsin Motallebzadeh
Anesthetist Nurse, Department of cardiac surgery, Razavi hospital, Mashhad, Iran