THE ANALGESIC EFFECT OF INTRANASAL KETAMINE AND IV MORPHINE IN PATIENTS WITH FLANK PAIN (RENAL COLIC) IN THE EMERGENCY DEPARTMENT: A CLINICAL TRIAL STUDY

Background and Aim : Renal colic is the most common clinical manifestation of urinary stones.This study was aimed to compare the effect of intranasal ketamine vs. intravenous morphine onrenal colic.Methods : In this clinical trial study, 100 patients with renal colic were entered into the study andrandomly divided into two groups. Patients in treatment group received intranasal ketamine (1.5mg/kg), and the other group was given intravenous morphine (0.1 mg/kg). The pain was measuredat 0, 5, 15, 30 and 60 minutes after medication administration.Results : In this study, 32% of patients were female and 68% were male. Also, the differencebetween the initial pain with pain at all subsequent times in the two groups were significant (P<0.001). The duration of the ketamine effect to control pain was longer, but with the administra t ionof morphine, a faster effect on pain relief was achieved.Conclusion : Low-dose ketamine is considered as an analgesic with low side effects, with simpleand uncomplicated usage that reduces the risk of the needle stick in pre-hospital conditions. Onthe other hand, IV morphine has a faster effect, therefore its use in patients with severe pain shouldbe given priority.

Keywords:

Acute , Pain , Care , Renal Colic , Emergency department , Intranasal , Ketamine , Morphine , Analgesic