Synthesis and In vitro Antibacterial activity of benzylamino coumarin derivative.

A simple method for the synthesis of benzylamino coumarin derivatives has been developed from secondary amines, aromatic aldehyde, and 4-hydroxy coumarin via Mannich type reaction in the presence of BF3.SiO2. In vitro antibacterial assay wasperformed against X. campestris pvs, P. syringae and P. carotovorum by using the disc diffusion method. Tetracycline was used asstandard drugs for the assay. Pectobacterium carotovorum is a bacterium of the family Enterobacteriaceae; it formerly was a member of the genus Erwinia. The species is a plant pathogen with a diverse host range, including potato, African violet, and other agriculturally and scientifically important plant species. It causes soft rot and blackleg of potato and vegetables, as well as slime flux on many different tree species. Xanthomonas can infect a wide variety of species including pepper, rice, citrus, cotton, tomato, broccoli, cabbage, and soybeans. Some types of Xanthomonas cause localized leaf spot or leaf streak while others spread systemically and cause black rot or leaf blight disease. pseudomonas syringae is responsible for causing diseases on over 180 plant species including fruit trees, vegetable crops and flowers. Pathovars of main economic importance in Europe are the pvs syringae, morsprunorum, avii and persicae, causing bacterial canker on sweet and sour cherry, plum, peach and apricot as well as in wild cherry.

Keywords:

Synthesis , In vitro Antibacterial activity , benzylamino coumarin , X. campestris pvs , P. syringae , P. carotovorum