Investigation of plasma C-reactive protein (CRP) level in diabetes

Globally, about 200 million people have diabetes, but experts believe this number will double by 2030. Ways to prevent or delay the onset of diabetes are, therefore, urgently needed. Some studies have shown the relationship between C-reactive protein (CRP) levels with type 2 diabetes. Therefore, the aim of this study was to examine the plasma CRP level in Iranian patients with type 2 diabetes. In the present study, 80 samples, including 40 patients with type 2 diabetes, and 40 healthy controls were collected. The level of CRP was investigated in type 2 diabetes patients and healthy controls by Enzyme-Linked Immunosorbent Assay (ELISA). Data were analyzed by SPSS software. Also, diabetes signaling pathway enrichment analysis performed on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Analysis of the level of CRP was a statistically significant difference (P -value<0/005). The level of CRP in type 2 diabetes increased compared to controls. The findings of the current study revealed the association between the level of CRP and prognosis in type 2 diabetes, at least in our patients studied. However, more in-depth and comprehensive investigations should be done.

Keywords:

Diabetes , C-reactive protein , Plasma