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Isolation of 17 Antidiabetic Compounds from Two Iranian Plants

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Year: 2019
COI code: HBHEAITH06_050
Paper Language: English

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Authors Isolation of 17 Antidiabetic Compounds from Two Iranian Plants

  Hossein Dehghan - Medicinal Plants Research Center, Shahed University, Tehran, Iran


The present study was aimed to investigate antidiabetic activities of Allium paradoxum, Buxus hyrcana, Convolvulus persicus, Eryngium caucasicum, Heracleum persicum, Pimpinella affinis, Parrotia persica, Primula heterochroma, Pyrus boissieriana, Rheum turkestanicum, Ruscus hyrcanus, and Smilax excels. In the following, the study was conducted to isolate active phytochemicals of the most potent plants, R. turkestanicum and H. persicum.A sequential extraction method used to obtain n-hexane, ethyl acetate, and methanol extracts of various parts of the plants. DPPH scavenging, α-amylase and α-glucosidase inhibition activities, and total phenolic contents of the extracts were investigated. The active compounds were isolated by column chromatography and identified by 1H-, 13C-, 2D-NMR, EI-MS and single-crystal X-ray diffraction.R. turkestanicum and H. persicum showed significant activities against α-glucosidase enzyme more effective than acarbose, a standard antidiabetic drug. As a result, 17 antidiabetic compounds were isolated from R. turkestanicum and H. persicum. Chrysophanol, physcion, emodin, daucosterol and rhododendrin were isolated from Rheum turkestanicum. Psoralen, bergapten, xanthotoxin, isopimpinellin, angelicin, isobergapten, sphondin, pimpinellin, heratomin, 5-methoxyheratomin, moellendorffiline, and fraxetin were isolated from H. persicum.Consequently, moellendorffiline and daucosterol introduced as new potent antidiabetic compounds, more potent than acarbose, an antidiabetic drug.


Iranian plants; Antidiabetic; Antioxidant; Moellendorffiline; Daucosterol.

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COI code: HBHEAITH06_050

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Dehghan, Hossein, 2019, Isolation of 17 Antidiabetic Compounds from Two Iranian Plants, The sixth national Conference of Medical Herbs Conventional Medicine and Organic Agriculture, همدان-مركز تحقيقات و آموزش كشاورزي ومنابع طبيعي استان همدان, انجمن علمي پژوهشي دانش پژوهان بوعلي سينا - مركز تحقيقات آموزش كشاورزي ومنابع طبيعي استان همدان, the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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The University/Research Center Information:
Type: state university
Paper No.: 3839
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