Aptamer and breast cancer

Cancer is one of the death reason in the world. Breast Cancer is the most common malignancy in the world. In almost 20-30percent of Breast Cancer ,we can see the over expression of HER2.The drug delivery to target tumor cells is performed by Aptamer (DNA or RNA oligonucleotide)that can bind to wide target molecules like drugs and proteins. This process is related to the increase of the effectiveness of chemotherapy and the decrease of toxicity of cell .Antibodies identify their own target cells. But Aptamer identify the large amount of molecules. By SELEX method (isolating systematic of Ligand by Expotential enrichment), Aptamer can be isolated for proteins, drug, or chemical structure.Material and Method: studies of reviewed article in 2010 _ 2013 Results: complex formed Aptamer _doxorubician .To consider the feasibility of this method, Apt_Dox was used as drug delivery system to the Breast Cancer Cells .And in HER2negative, Apt_Dox causes todecrease the toxicity in Breast Cancer Cells and it was compared in HER2possitive with cytotoxic free apt_dox and Dox that causes selective delivery. Discussion;Aptamers can bind to the target cell by their own high affinity and special specificity, and can be used for targeting the Ligand in selective drug delivery.

Keywords:

Aptamer , Breast Cancer , HER2