Breast cancer with Acrometastasis Of hands, two case reports from Ostad Alinasab Hospital inTabriz(north west of Iran).

Publish Year: 1393
نوع سند: مقاله کنفرانسی
زبان: English
View: 415

نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

  • Certificate
  • من نویسنده این مقاله هستم

این Paper در بخشهای موضوعی زیر دسته بندی شده است:

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

ICBCMED10_125

تاریخ نمایه سازی: 21 اردیبهشت 1397

Abstract:

Bone metastases are frequently seen in patients with malignancies,up to 70% in breast cancer, but approximately only %0/1-0/3% of these metastases are located in the hand or foot. In 16%ofpatients, acrometastasis is the first manifestation of a malignancy, mimicking a benign condition , the lesion will appear similar to that of an infection or inflamation ,and often present with pain, redness or discoloration,tenderness , heat , swelling , erythema, or loss of function.The mechanism responsible for the deposition of metastatic tumour cells within the hand is unclear, but an increase in blood flow or a trauma has been suggested in the past, and more recently, it has been suggested that the chemotactic factors (prostaglandins)and angiogenesis and growth factors has anyrols, and most in the dominant hand.The most commonly involved bones are the phalanges in the hand and the tarsal bones in the foot. Theseacrometastasishave a poor prognosis with a median survival of 6month, and early diagnosis isimportant to offer adequate treatment. Amputation, radiotherapy , curettage , cementation , chemotherapy , bisphosphonates , and wide excision are the forms of treatment used most often. CASE ONE :The 51 years old woman with 5years past history of right side breast carcinoma ( T2N2M0-ER+,PR+,HER2_ ,8course CA/T chemotherapy and 50GY radiation therapy-4years tamoxifen therapy (20mg daily), alendronate 70mg weekly , Calcium D(3 tab per day) ) referred for pain and redness and inflammatory state in first metacarpal of right hand , and lytic destructive bone lesionin the first metacarp… CASE TWO: the 32year-old woman referred to our clinic with a two week history of right index finger pain,redness,and swelling without any history of trauma.The pain did not respond to NSAIDs ,narcotics and antibiotics.Inphysical examination revealed a mass like bone lesion in proximal phalanx of right index finger. An X-ray of his right hand lytic and destructive bon lesion in proximal phalanx of the right index finger . She subsequently underwent biopsy of the finger lesion . Pathology from the specimen revealed a metastatic adenocarcinoma , most probably from breast or lung (primary lesion ).CT scan of thorax and abdomen and pelvic was normal , but in digital mammography andsonography of breasts, a 7mm lesion was seen in left breast (outer upper quadrant ) , and pathology of this lesion in biopsy was invasive ductal carcinoma. Acrometastasis in this case is a first presentation of breast carcinoma.

Authors

Alikaram Hedayati Godarzi

professor of medical oncology, Consultant of OstadAlinasab Hospital in Tabriz

Fatemeh Hedayati

professor of medical oncology, Consultant of OstadAlinasab Hospital in Tabriz

Zahra Mokarram Ghazani

professor of medical oncology, Consultant of OstadAlinasab Hospital in Tabriz

Mohammad Hedayati.

professor of medical oncology, Consultant of OstadAlinasab Hospital in Tabriz