Clinical significance of Dkk-3 serum level as new biomarker in breast cancer

Publish Year: 1394
نوع سند: مقاله کنفرانسی
زبان: English
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ICBCMED12_173

تاریخ نمایه سازی: 2 تیر 1397

Abstract:

Introduction and Aim: The serum level of Dickkopf-3 (Dkk-3), a secreted Wnt family protein is changed in patients suffering various types of cancers. The aim of this study was to investigate the diagnostic value of Dkk-3 as new biomarker in breast cancer and comparing with CA15-3 as common breast cancer biomarker.Materials and Methods: Breast cancer samples were obtained from 29 patients referring to Iran national bank, Imam Khomeini Hospital, Tehran, Iran and 20 healthy controls. Estrogen receptor (ER), progesterone receptor (PR) and HER-2 positive and negative in patients were defined. Significance and diagnostic performance including receiver operator characteristic (ROC) and areas under the curve (AUC) were determined by SPSS software. Results: Serum level of Dkk-3 was significantly decreased in patients compared to the healthy control (4.72±1.75 vs 19.8±2.3 respectively) (P˂0.001). Conversely, the expression levels of CA15-3 was increased in patients suffering breast cancer in comparison with healthy women (12.2±6.4 vs 8.9±3.4 respectively) (P˂0.001). ROC- AUC for Dkk-3 and CA15-3 were 0.89 and 0.62 respectively. Sensitivity and specificity of Dkk-3 were more than CA15-3 especially in earlier stages of breast cancer (95.6 vs 86.3 and 73.07 vs62.9 respectively). Dkk-3 expression in HER-2, ER and PR positive patients was more decreased in contrastwith PR and ER negative patients (P<0.001). Conclusion: Our data showed that serum level of Dkk-3 decreased in patients with breast cancer. So, this study indicated that serum level of Dkk-3 may be a useful biomarker in breast cancer.

Authors

Hemn Mohammadpour

Department of Immunology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran

Samaneh Khorrami

Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Salahadin Bahrami

Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

Ghasem Mosayebi

Molecular and Medicine Research Center, Department of Immunology, Arak University of Medical Sciences, Arak, Iran