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Study of miR-30-3p expression profile in human breast cancer

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Year: 2017
Present: پوستري
COI code: ICBCMED13_006
Paper Language: English

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Authors Study of miR-30-3p expression profile in human breast cancer

Roya Gholami - Faculty of Nursing and Midwifery, Islamic Azad University of Shahrekord Branch, Shahrekord, Iran
  Asghar Arshi - Young Researchers and Elite Club, Najafabad Branch, Islamic Azad University, Najafabad, Iran


Introduction & Aim: MicroRNAs (miRNAs) are small non-coding RNAs that contribute to modulating signaling pathways after radiation exposure and have emerged as a potential therapeutic target or biomarker in the radiation response of cancer. miR-30-3p has tumor suppressive function through the mechanism underlying transcriptional repression of KRT7. This study was aimed to compare miR-30-3p expression profile in human breast cancer using RT-qPCR.Methods: Twenty samples from patients with breast cancer and twenty samples from non-tumor were collected by a pathologist specialist. After RNA extraction from tumoral and normal tissue samples, cDNA was synthesized according to protocol and RT-qPCR carried out using SYBR®Premix Ex TaqTM II kit. miR-30-3p expression profile was analyzed by ΔΔCT method.Results: Our results revealed that the mean of miR-30-3p expression profile in human breast cancer is down-regulated in comparison with control group.Conclusion: Overall, the results of the present study revealed distinct differences in the expression profile of miR-30-3p to control group (down-regulation of miR-30-3p), and this miRNA can be used as biomarkers for cancer therapy.


miR-30-3p, Breast cancer, RT-qPCR

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COI code: ICBCMED13_006

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Gholami, Roya & Asghar Arshi, 2017, Study of miR-30-3p expression profile in human breast cancer, 13th International Congress on Breast Cancer, تهران, دانشگاه علوم پزشكي شهيد بهشتي, the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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