Published in: 13th International Congress on Breast Cancer
COI code: ICBCMED13_006
Paper Language: English
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Authors Study of miR-30-3p expression profile in human breast cancerRoya Gholami - Faculty of Nursing and Midwifery, Islamic Azad University of Shahrekord Branch, Shahrekord, Iran
Asghar Arshi - Young Researchers and Elite Club, Najafabad Branch, Islamic Azad University, Najafabad, Iran
Abstract:Introduction & Aim: MicroRNAs (miRNAs) are small non-coding RNAs that contribute to modulating signaling pathways after radiation exposure and have emerged as a potential therapeutic target or biomarker in the radiation response of cancer. miR-30-3p has tumor suppressive function through the mechanism underlying transcriptional repression of KRT7. This study was aimed to compare miR-30-3p expression profile in human breast cancer using RT-qPCR.Methods: Twenty samples from patients with breast cancer and twenty samples from non-tumor were collected by a pathologist specialist. After RNA extraction from tumoral and normal tissue samples, cDNA was synthesized according to protocol and RT-qPCR carried out using SYBR®Premix Ex TaqTM II kit. miR-30-3p expression profile was analyzed by ΔΔCT method.Results: Our results revealed that the mean of miR-30-3p expression profile in human breast cancer is down-regulated in comparison with control group.Conclusion: Overall, the results of the present study revealed distinct differences in the expression profile of miR-30-3p to control group (down-regulation of miR-30-3p), and this miRNA can be used as biomarkers for cancer therapy.
Keywords:miR-30-3p, Breast cancer, RT-qPCR
COI code: ICBCMED13_006
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Gholami, Roya & Asghar Arshi, 2017, Study of miR-30-3p expression profile in human breast cancer, 13th International Congress on Breast Cancer, تهران, دانشگاه علوم پزشكي شهيد بهشتي, https://www.civilica.com/Paper-ICBCMED13-ICBCMED13_006.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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