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Association between mir-146a rs2910164 gene polymorphism and breast cancer recurrence

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Year: 2017
Present: شفاهي
COI code: ICBCMED13_130
Paper Language: English

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Authors Association between mir-146a rs2910164 gene polymorphism and breast cancer recurrence

  Sareh Rahimi - Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran Young Researchers and Elite Club, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran.
  Leila Kohan - Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran Young Researchers and Elite Club, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran.
  Mohammad Mohammadianpanah - Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  Majid Akrami - Breast Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract:

Introduction: Breast cancer is the most common form of cancer in women. Several studies in recent years reported that mutations and Single nucleotide polymorphisms (SNPs) in miRNAs are associated with the risk of various cancers. Methods: This study was performed on 267 breast cancer patients, 156 patients without recurrence of breast cancer and 111 patients with relapsing disease. After DNA extraction, genotyping was done using Tetra ARMS PCR technique. Statistical analysis of data was done using logistic regression model.Results: The results were shown that there was no significant association between mir-146a rs2910164 polymorphism with the breast cancer recurrence.Conclusions: The present study is a first study to investigate association between mir-146a rs2910164 gene polymorphism and breast cancer recurrence. Based on the results of this study, it seems that the microRNA-146a rs2910164 polymorphism does not interfere with the pathogenesis of breast cancer recurrence.

Keywords:

Breast cancer recurrence, mir-146a, polymorphism, micro RNA

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COI code: ICBCMED13_130

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Rahimi, Sareh; Leila Kohan; Mohammad Mohammadianpanah & Majid Akrami, 2017, Association between mir-146a rs2910164 gene polymorphism and breast cancer recurrence, 13th International Congress on Breast Cancer, تهران, دانشگاه علوم پزشكي شهيد بهشتي, https://www.civilica.com/Paper-ICBCMED13-ICBCMED13_130.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Rahimi, Sareh; Leila Kohan; Mohammad Mohammadianpanah & Majid Akrami, 2017)
Second and more: (Rahimi; Kohan; Mohammadianpanah & Akrami, 2017)
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The University/Research Center Information:
Type: Azad University
Paper No.: 906
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