Design and in-vitro evaluation of drug in adhesive nitroglycerin transdermal patches

Transdermal systems are among Novel Drug Delivery Systems and are attributed to the systems havingproperty of diffusing drugs through skin in a noninvasive form by delivering drugs into systemic bloodcirculation which as a consequence the drug effects appears. Within two pervious decades, transdermaldrug delivery has been the core of interest of many pharmaceutical research and chemical and polymerengineering studies. Constant blood level, non-hepatic first pass effect, patience compliance areadvantages of these systems compare to oral administration and intravenous infusion. The greatestlimitation in developing these systems is impermeability of stratum corneum. This study targeted toDesign & In-vitro evaluation of Transdermal Drug Delivery System for Nitroglycerin for thetreatment of angina pectoris. Permeation enhancers under study were various kinds of hydrophils andhydrophobs. Oleic acid and cetyl alcohol from hydrophobs and propylene glycol from hydrophils wereselected. Drug-in-adhesive patches were studied from point of view of dissolution method. Finally therelease profile of nitroglycerin from different drug-in-adhesive patches containing different pressuresensitive adhesives and chemical permeation enhancers were determined. The conclusion was thatrelease profile of nitroglycerin from different formulations depends on viscosity and type of pressuresensitive adhesive and type and concentration of selected chemical permeation enhancer.

Keywords:

Transdermal Drug Delivery , In-vitro Evaluation , Nitroglycerin Patches , Drug Release