Studying the frequency of resistance to Metallo Beta Lactamase in the separated Klebsiella Pneumoniae in AlZahra Hospital of Tabriz

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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ICCM12_059

تاریخ نمایه سازی: 1 دی 1397

Abstract:

Background :Metallo Beta Lactamase enzymes have an important role in making the resistance against various antibiotic factors particularly beta-lactams and carbapenems. Today, the resistant Klebsiella pneumoniae to carbapenem is considered as one of the important hospital infections and have made many medical problems. This research aims at studying the frequency of the Metallo Beta Lactamase enzyme in the separated Klebsiella Pneumoniae species from the referring women urethral infection to AlZahra hospital of Tabriz city.Method and material: This study was conducted on 160 isolates of Klebsiella pneumoniae isolated from urine specimens in women referred to Alzahra Hospital in Tabriz. The Standard disk diffusion method (Kirby Bauer) was used to determine the antibiotic resistance model. Combined disk method (Imipenem-Imipenem + EDTA) was used to isolate the isolates of metallo-β-lactamase producer.Results: Klebsiella Pneumoniae species have the maximum resistance against Ampicillin with 100% resistance and the minimum resistance to the Ciprofloxacin antibiotic with 33.125%.108 (67.5%) isolates were resistant against imipenem and the obtained results from the combined88disk (Imipenem-Imipenem + EDTA) showed that 34.04% of isolates produce Metallo Beta Lactamase.Conclusion: results of this research showed that the metalobetalactamas productive enzymes in the Klebsiella Pneumoniae isolates are high in this research. The existence of such resistance can be a caution for the present medical protocol.

Authors

Niloofar Vatandust

Department of Microbiology,higher education institute of Rab-Rashid Tabriz,Tabriz,Iran

Mehdi Ghiami Rad

Department of Microbiology, Islamic Azad University of Ahar, Ahar, Iran

Mahnaz Rasooli

Department of Microbiology, Islamic Azad University of Ahar, Ahar, Iran