Determination of Antibiotic Resistance and plenty extended-spectrum beta lactamases in Pseudomonas aeruginosa Strains Isolated from Patients Hospitalized in a Burn Ward in Tehran

Background and Objectives: Pseudomonas aeruginosa is one of the most important causes of hospital infections and can be resistant to many antibiotics. The aim of this study was to evaluate the prevalence of extended-spectrum beta lactamases (ESBL) and antimicrobial resistance of Pseudomonas aeruginosa in patients hospitalized in the burn ward of Erfan Hospital in Tehran. Materials and Methods: In this study, 20 strains of Pseudomonas aeruginosa were isolated from patients in the burn ward of Erfan Hospital and identified by biochemical tests. Resistance to 7 antibiotics was determined by disc diffusion method. To study ESBL production, a combination and double discs was performed. Results: The antibiotic resistance rates used in this study were: Cefotaxime and Ceftriaxone (100%), Meropenem (93.75%), Imipenem (85.40%), Piperacillin+ Tazobactam (81.25%) and Ceftazidime (55%). And the plenty of ESBL production (15%) is identified. Conclusion: Pseudomonas aeruginosa is resistant to multi drugs and is considered a major risk in hospitalized patients .In this study, only 15% of isolates have produced ESBL. Therefore, in these bacteria,other mechanisms than extended-spectrum beta lactamases produce resistance, and rapid identification is important in preventing their spread.