A Simple, Convenient and Eco-Friendly Method for the Synthesis of 2,4,5-trisubstituted-1H-imidazoles Catalyzed by Vitamin B12 Under Solvent-Free Conditions
Publish place: First International Congress of Chemistry and Nanochemistry from Research to Technology
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ICCNRT01_159
تاریخ نمایه سازی: 30 دی 1397
Abstract:
A simple, highly efficient and eco-friendly protocol for the synthesis of 2,4,5-trisubstituted-1H-imidazoles via one-pot three component condensation of benzil, aldehydes and ammonium acetate under solvent-free conditions has been achieved utilizing vitamin B12 as catalyst. This methodology has number of advantages such as: use of green and nonhazardous catalyst, clean work up, solvent-free conditions, short reaction times, high yields and no need to column chromatography.
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Authors
Zeinab Imani
Department Of Chemistry, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran
Seyed Mahdi Saadati
Department Of Chemistry, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran