Association Analysis between rs10830962 Variant of MTNR1B Gene and Type 2 Diabetes Mellitus Risk

Introduction: Type 2 diabetes mellitus (T2DM) is one of the major global health problems around the world. It is a common complex metabolic disorder that has a strong genetic component. Genetic variants of melatonin receptor 1B (MTNR1B) have been associated with type 2 diabetes mellitus (T2DM) and whether MTNR1B variants are associated with type 2 diabetes mellitus (T2DM) in Iranian patients remains unclear. The aim of the study was to examine the association between MTNR1B (rs10830962) gene polymorphisms and the risk of T2DM in a group of Iranian patients.Materials & Methods: Genotyping was carried out in a total number of 208 subjects, including 108 patients with T2DM and 100 normal controls using Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP).Results: The frequencies of CC,GC and GG among cases were 54.63%, 1.85% and 43.52% and in control subjects were 81%, 0% and 19% respectively. Frequency of G allele among diabetic patients was significantly higher than that among non-diabetics (p<0.001). The odds ratio for G allele was 3.34 (p<0.001).Conclusion: We observed that presence of rs10830962 genotype was significantly higher among diabetic patients compared to normal population. In addition, the presence of G allele significantly increased the risk of diabetes more than three folds. In conclusion, our study showed that rs10830962 polymorphism of MTNR1B gene can be directly associated with type 2 diabetes mellitus.