Genetic Variant of GIPR Gene and the Risk of Type 2 Diabetes

Introduction: Type 2 diabetes mellitus (T2DM), as a worldwide health problem, is a multifactorial disease that environmental and genetic factors contribute to its pathogenesis. Gastric Inhibitory Polypeptide Receptor (GIPR) is a G-pro receptor which controls the gut hormones and insulin secretion. The present study aimed to investigate the role of GIPR rs1800437 gene variant in T2DM susceptibility.Materials & Methods: 108 confirmed T2D patients and 100 normal controls were recruited in the study. The GIPR rs1800437 SNP was determined by PCR-Restriction Fragment Length Polymorphism (RFLP) assay.Results: A significant difference was not found in genotypes (CC, CG, and GG) frequency of GIPR rs1800437 SNP between T2DM and control groups. Frequencies of GG, GC and CC genotypes among the patients were 38.89%,4.63%and56.48% and in the controls were 26%,1% and 73% respectively. Frequency of C allele among cases was significantly lower than that among controls (p=0.002)(OR=0.51).Conclusion: We observed that patients with type 2 diabetes compared with the normal population had significantly lower frequency of the genotype of rs1800437 polymorphism of GIPR gene.Among diabetic patients no difference was observed between C or G allele carriers regarding their HbA1c therefore presence of this polymorphism cannot affect the results of the treatment.