Evaluation of leptospira interrogans outer membrane protein Ompl37 linear and conformational epitopes

Publish Year: 1394
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

ICESCON02_225

تاریخ نمایه سازی: 16 شهریور 1395

Abstract:

Leptospirosis is a tropical, neglected, zoonotic disease caused by pathogenic spirochetes of the Leptospira genus. It is typically associated with inadequate sanitation, poverty, and recreational or professional activities that involve exposure to known risk factors(1-2). Transmission occurs mainly through direct or indirect contact with the contaminated urine of reservoir animals[3]. The infection is endemic wherever there is exposure to urine of reservoir host animals that harbor the organism in their renal tubules. Commercially available vaccines are bacterin-based (killed whole cells), do not provide cross-protection against different serovars, confer only short-term immunity and usually fail to prevent the transmission of the disease [11-12]. Efforts to develop recombinant vaccines against leptospirosis have focused on conserved outer membrane proteins (OMPs) that represent potential targets for immunological defence mechanisms. The aim of this study was to characterize and evaluate the linear and conformational epitopes of the outer membrane protein Ompl37 in leptospira interrogans as a vaccine candidate.

Keywords:

Linear and conformational epitopes , Ompl37 , vaccine candidate , leptospira

Authors

Afsane Bastani Allah abadi

Departeman of biology, Science and Art University, Yazd, Iran

Fateme Sefid

Department of Biology, shahed University ,Tehran-Qom Express Way

Sara sabet

Departeman of biology, Science and Art University, Yazd, Iran

Sadaf Jelvani

Departeman of biology, Science and Art University, Yazd, Iran

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