HN-01050247_Association between Arterial Stiffness Markers and Physical Activity, Anthropometry and Lipid Profiles

Introduction: Arterial stiffness (AS) results from a degenerative process, indicating the initial stage of cardiovascular disease (CVD), which may be associated with behavioral risk factors, such as physical inactivity, obesity, and chronic inflammation. Due to the controversial results of studies, we have conducted this nested cross-sectional study within PERSIAN cohort study to examine the association of AS with anthropometric parameters, lipid profiles and physical activity (PA).Methods: Seven hundred healthy adults aged between 30-70 years were selected. Carotid-femoral pulse wave velocity (cfPWV) was used for assessment of AS markers, including cfPWV, augmentation pressure (AP), central augmentation index (cAIx), and arterial age (AA). Anthropometric parameters, PA and lipid profiles containing TGs, HDL-C and cholesterol were measured.Results: CfPWV was positively related to TGs, cholesterol, PA, a body shape index (ABSI), and waist to hip ratio (WHR). AP was positively related with TGs, cholesterol, BMI, WHR and body fat mass (BFM). Also, Positive correlation for AA only observed with BFM, WHR and TGs. After adjustment for cofounders, cfPWV was only associated with TGs (P=0.01, β=0.13) and BFM (P=0.02, β=-2.07). AA was related to TGs (p=0.03, β= 0.1) and WHR (P=0.02, β= 2.52); However, no association was observed between AP, cAIx and any of the evaluated factors.Conclusions: Data showed the association of cfPWV and AA with TGs, BFM and WHR. TGs were positively associated with AA and cfPWV, and BFM was inversely associated with cfPWV. Therefore, improvement in TGs and WHR could improve AS markers, which may be considered in CVD prevention.