HN-00960105_The Effect of Dietary Glycemic Index on Inflammatory Biomarkers in Hospitalized Patients

Background: Glycemic index indicates as increasing in blood glucose, two hours after eating carbohydrate foods. the effect of sugar on inflammatory cytokines has been proved. By relying on these findings, some references and studies classified foods with high Glycemic index as inflammatory foods. In this review, we consider to assess the effect of Glycemic index on inflammatory biomarkers.Methods: We conduct a comprehensive search in Medline, Up-to-date and PubMed databases for trials, case-control and meta-analysis studies from 2015 till now. Total of 61 studies has been found. Forty-four of them was excluded because lack of consideration of inflammatory biomarkers and full article of total of 13 studies reviewed.Results: Dietary pattern with high glycemic index could increase TNF-a, IL-6 and CRP but this increase was significant only in CRP. Although carbohydrates are classified as inflammatory foods, there is no evidence to support this thesis and prove that, dietary Glycemic Index have a direct effect on rise of inflammatory biomarkers. The increases in these factors in some studies can be explained by hyperglycemia, obesity, oxidative stress, and cell death during rapid increase in insulin level specially in diabetes patients.Conclusions: there is no direct effect of glycemic index on inflammatory biomarkers. However, by considering the effect of Glycemic index on insulin level and weight gain in long term, we have to concern about the long term effect of using high glycemic index foods on the potential of systematic inflammations in future.

Keywords:

Glycemic Index , Inflammation , cytokine , inflammatory biomarker