HN-01740124_Effect of probiotics and synbiotics on selected anthropometric and biochemical measures in women with polycystic ovary syndrome: A systematic review and meta-analysis

Introduction: This study aimed to systematically review randomized clinical trials (RCTs) to clarify the effects of pro-/synbiotic supplementation on anthropometric and biochemical measurements in women with polycystic ovary syndrome (PCOS).Methods: PubMed, Scopus, ISI Web of Science, Cochrane Library, and Google Scholar were searched through September 2018. Eight RCTs (nine treatment arms) were included.Results: Pro-/synbiotic supplementation significantly reduced fasting blood sugar (−2.52 mg/dl, 95% confidence interval (CI): −4.10 to −0.95), insulin (−2.27 μIU/mL, 95% CI: −3.40 to −1.14), homeostasis model assessment for insulin resistance index (−0.69, 95% CI: −0.98 to −0.40), C-reactive protein (−1.69 Hedges’, 95% CI: −3.00 to −0.38), and total testosterone (−0.12 ng/mL, 95% CI: −0.17 to −0.08) in women with PCOS.Conclusion: However, changes in the mean difference of weight and body mass index did not reach a statistically significant level. The findings suggest that pro-/synbiotic supplementation may improve glucose homeostasis parameters, hormonal, and inflammatory indices in women with PCOS.

Keywords:

probiotics , meta-analysis , synbiotics , systematic review , polycystic ovary syndrome