HN-01760130_Effects of N-Acetylcysteine Supplementation on Anthropometric Assessments in Patients with Multiple Sclerosis: A Double-Blind Randomized Controlled Trial

Introduction: The current study was designed to determine the effects of N-Acetylcysteine (NAC) supplementation on the anthropometric indices in patients with multiple sclerosis (MS).Methods: This randomized double-blind placebo-controlled clinical trial was conducted on 54 MS patients. Participants were randomly assigned to NAC (n=27) or placebo (n=27) groups. Patients in the NAC group received a daily dose of 1200 mg NAC (two 600mg effervescent tablets a day), dissolved in a glass of water for 2 months, and the control group received placebo tablets for the same period. Body Mass Index (BMI), weight and waist circumference were recorded before and 2 months after the intervention.Results: After 8 weeks of intervention, NAC supplementation resulted in no significant change in weight (0.38±1.51 vs. 0.33 ±1.38, P=0.9), BMI (0.18±0.56 vs. 0.13 ±0.47, P=0.7), and Waist circumference (0.14 ±0.85 vs. 0.00 ±1.09, P=0.6) compared with the placebo.Conclusion: Overall, the results of this study indicated that NAC supplementation for 8 weeks had no effects on the anthropometric indices in patients with MS.