Therapeutic Effects of Aqueous Extracts of Cerasus avium Tail on Ethylene Glycol- Induced Kidney Calculi in Rats
Publish place: دومین کنفرانس بین المللی پژوهش در علوم و مهندسی
Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ICRSIE02_237
تاریخ نمایه سازی: 11 مرداد 1396
Abstract:
Aim: to investigate the therapeutic effects of the aqueous extract of cherry tails on kidney calculi. Methods: In this experimental study, forty-eight (48) male Wistar rats were randomly allocated into six (6) groups and were studied during a 30 day period. Group A served as normal control and Group B received 1% ethylene glycol in drinking water(EG group). C,D,E, and F Groups, received 1% ethylene glycol from day 1 and were used as prevention and treatment subjects. Rats in prevention groups of low dose (C) and high dose (D) extract, were gavaged with 200 and 400 mg/kg extract respectively from first day of the experiment and treatment groups of low dose (E) and high dose (F) extract, gavaged with 200 and 400 mg/kg extract respectively from the 15th day of the experiment. Results: On the 30th days of the experiment, serum level of magnesium and potassium decreased significantly in EG group compared with A,C,D,E and F groups (P<0.05), while serum level of calcium and sodium increased significantly in EG group compared with A,C,D,E and F groups (P<0.05). In the prevention and treatment groups, the number of deposits decreased significantly compared with EG group on the 30th day (P<0.01). The weight of the kidneys increased significantly in EG group compared with A,C,D, and F groups. Conclusion: Cherry tail has a therapeutic effect on calcium oxalate stones in rats with nephrolithiasis and reduces the number of calcium oxalate deposits.
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Authors
Ehsaneh Azaryan
Biochemistry Department, payamenoor university of Mashhad, Mashhad,Iran
Mohammad malekaneh
Biochemistry Department, Birjand Uniniversity of Medical sciences, Birjand, Iran
Fatemeh Haghighi
Pathology Department, Birjand Uniniversity of Medical sciences, Birjand, Iran