Synthesis, characterization and DNA-binding studies of a metal complexes of anthranilic acid

The project first synthesizes, detects and investigates the spectroscopy of complexes of Ni, Cu and Zn binomial intermediates with anthranilic acid ligands. Synthesized complexes characterized using FT-IR, UV-vis and 1H-NMR. The electron spectra of these complexes have absorption bands in the region of 200-400 nm and intra-ligand transitions (n → π *, π → π *) of anthranic acid. Bands in the range of 400-800 nm attributed to d-d transitions. The results obtained from the 1H NMR study are also consistent with the theoretical results [1]. Investigation of the interaction of synthetic complexes with DNA at 298, 300 and 310 Kelvin temperatures was carried out using electron-absorption spectrophotometry technique, and ?? was obtained for the bonding of the complex with DNA. The thermodynamic parameters, such as ΔG °, ΔH ° and ΔS °, were calculated [2].