Mn complex immobilized on CuFe2O4magnetice nanoparticles as an efficient heterogeneous catalyst for the synthesis of 5-substituted 1H-tetrazoles
Publish place: 21th Iranian Inorganic Chemistry Conference
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
IICC21_204
تاریخ نمایه سازی: 5 آذر 1398
Abstract:
Tetrazoles are an important class of heterocycles with wide range of application in coordination chemistry as ligands, in medicinal chemistry as stable surrogates for carboxylic acids, in catalysis technology, in organometallic chemistry as effective stabilizers of metallopeptide structures, in material chemistry as explosives, rocket propellants, etc., and in agriculture. Tetrazoles can be used as isosteric replacements for carboxylic acids in drug design and have found application in various material sciences, including photograph and information recording systems. Also, tetrazoles and their derivatives have been reported as analgesics, antifungal, ant-inflammatory, antibacterial, antiviral and anti-proliferative agents, potential anti-HIV drug candidates and anticancer agents. Valsartan and losartan are two typical examples of the extensive application of these compound in drugs, such as antihypertensive sartan family drugs [1,2].In this work, tetrazole derivatives were synthesis from reaction between nitrile derivatives with sodium azide in the presence of Mn complex immobilized of CuFe2O4 magnetic nanoparticles (Fig.1). Then; to determine the best reaction conditions, the effect of various parameters such as solvent, temperature, amount of NaN3 and amount of catalyst were examined in the cycloaddition reaction of benzonitriles with NaN3.
Authors
Samira Saeednia
Department of Chemistry, Faculty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran
Mehdi Hatefi Ardakani
Department of Chemistry, Faculty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran
Reza Ranjbar Karimi
Department of Chemistry, Faculty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran
Maryam Yousefizadeh Arjas
Department of Chemistry, Faculty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran