Functionalized Magnetic Nanocatalysts Based on Tris-(Hydroxy methyl)amino methane/Triazine as a new inorganic/organic hybrid catalyst for Synthesis of 3,4- dihydropyrano[c]chromene derivatives

The preparation and the use of inorganic/organic hybrid nanoparticles (HNPs) in organic synthesis has become a subject of intense investigation. In particular, functionalized magnetic nanoparticles (MNPs) which offer advantages in clean and sustainable chemistry as they can be non-toxic, readily available, and recoverable.1 Dihydropyrano[c]chromenes and their derivatives possess a wide range of biological properties such as anti-cancer, anticoagulant, diuretic, and anti-anaphylactic activities.2 Therefore, as the importance of these compounds, recently, design of novel nano hybrid catalysts magnetically separable in synthesis of these compounds have been attracted attention.In this work, mixture of several aromatic aldehydes (1mmol), malononitrile (1mmol) and 4-hydroxycoumain(1mmol) in around bottom flask and catlyst (0.02 g) were stirred at room temperature and solvent free conditions for required time. After completion of reaction, the catalyst easily collected by a magnet to be reused in subsequent reactions [1-3]. The obtained products were recrystallized in ethanol and characterized by 1HNMR, IR and 13CNMR.