CIVILICA We Respect the Science
Publisher of Iranian Journals and Conference Proceedings
Paper
title

VITAMIN D3 INDUCES GENE EXPRESSION OF OX-LDL SCAVENGER RECEPTORS IN STREPTOZOTOCIN-INDUCED DIABETIC RAT AORTAS: NEW INSIGHT INTO THE ROLE OF VITAMIN D IN DIABETIC ATHEROSCLEROSIS

Credit to Download: 0 | Page Numbers 1 | Abstract Views: 67
Year: 2018
COI code: INC15_004
Paper Language: English

How to Download This Paper

For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.

Authors VITAMIN D3 INDUCES GENE EXPRESSION OF OX-LDL SCAVENGER RECEPTORS IN STREPTOZOTOCIN-INDUCED DIABETIC RAT AORTAS: NEW INSIGHT INTO THE ROLE OF VITAMIN D IN DIABETIC ATHEROSCLEROSIS

  Shahab Alizadeh - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Abstract:

Background and Aim: Several lines of evidence suggest that oxidized LDL (Ox-LDL) scavenger receptors play a crucial role in the genesis and progression of diabetic atherosclerosis. This study aimed to elucidate the effect of vitamin D3 on gene expression of lectin-like oxidized LDL receptor-1 (LOX-1), scavenger receptor-A (SR-A), Cluster of Differentiation 36 (CD36), and Cluster of Differentiation 68 (CD68) as the main Ox-LDL receptors in streptozotocin (STZ)-induced diabetic rat aortas.Methods: Eighteen Sprague-Dawley rats were randomly divided into three groups of six rats each. Two rats died during the study so five rats from each group were analyzed at the study’s end. Diabetes was induced in overnight starved rats in two of the groups by intraperitoneal injections of 60 mg/kg of STZ. The vitamin D3/diabetic group then received weekly intraperitoneal injections of 5000 IU/kg of vitamin D3 dissolved in cottonseed oil for four weeks, diabetic controls received cottonseed oil, and healthy controls received sterile saline weekly for the same period. At the end of the four-week study period the animals were killed and the aortas were collected to examine the mRNA expression using real-time polymerase chain reaction (RT-PCR). SR-A and CD36 mRNA expression were significantly greater in the vitamin D3/diabetic rats than in both the diabetic control and healthy control rats. CD68 and LOX-1 expression were greater in the vitamin D3/diabetic rats than in the diabetic control and healthy control rats, respectively.Conclusion: Vitamin D3 may increase the risk of diabetic atherosclerosis by inducing scavenger receptors expression.

Keywords:

Atherosclerosis, Diabetes, Ox-LDL, Scavenger receptor

Perma Link

https://www.civilica.com/Paper-INC15-INC15_004.html
COI code: INC15_004

how to cite to this paper:

If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Alizadeh, Shahab, 2018, VITAMIN D3 INDUCES GENE EXPRESSION OF OX-LDL SCAVENGER RECEPTORS IN STREPTOZOTOCIN-INDUCED DIABETIC RAT AORTAS: NEW INSIGHT INTO THE ROLE OF VITAMIN D IN DIABETIC ATHEROSCLEROSIS, Third International Congress and Fifteenth Iranian Nutrition Congress, تهران, دانشگاه علوم پزشكي شهيد بهشتي - انجمن تغذيه ايران،انستيتو تحقيقات تغذيه اي و صنايع غذايي كشور،انجمن علمي تغذيه ايران, https://www.civilica.com/Paper-INC15-INC15_004.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Alizadeh, Shahab, 2018)
Second and more: (Alizadeh, 2018)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)

Scientometrics

The University/Research Center Information:
Type: Medical University
Paper No.: 6412
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.

Research Info Management

Export Citation info of this paper to research management softwares

New Related Papers

Iran Scientific Advertisment Netword

Share this paper

WHAT IS COI?

COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.