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ANTI-DIABETIC EFFECT OF Β-D-MANNURONIC ACID (M2000) AS A NOVEL NSAID WITH IMMUNOSUPPRESSIVE PROPERTY ON INSULIN PRODUCTION, BLOOD GLUCOSE, AND INFLAMMATORY MARKERS IN THE EXPERIMENTAL DIABETES MODEL

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Year: 2018
COI code: INC15_082
Paper Language: English

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Authors ANTI-DIABETIC EFFECT OF Β-D-MANNURONIC ACID (M2000) AS A NOVEL NSAID WITH IMMUNOSUPPRESSIVE PROPERTY ON INSULIN PRODUCTION, BLOOD GLUCOSE, AND INFLAMMATORY MARKERS IN THE EXPERIMENTAL DIABETES MODEL

  Shahab Alizadeh - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Abstract:

Background and Aim: glucose, insulin production, and inflammatory markers in streptozotocin-induced diabetic rats.Methods: Our data showed that the final fasting serum glucose level was significantly lower in the M2000-treated group compared to the diabetic control group (p<.05). In addition, the final fasting serum insulin level significantly increased in the M2000-treated group compared to the diabetic control group (p<.05). Our finding revealed that the serum level of hs-CRP and IL-6 decreased significantly in the M2000-treated group compared to the diabetic control group (p<.05). This study showed that M2000, as a new NSAID, was able to decrease serum glucose levels and increase serum insulin levels and this drug could significantly decrease the inflammatory markers in the M2000-treated group.Conclusion: Collectively, treatment with M2000 might be recommended reducing the severity of diabetes-induced inflammatory symptoms.

Keywords:

M2000; NSAID; blood glucose; insulin; inflammatory markers

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Alizadeh, Shahab, 2018, ANTI-DIABETIC EFFECT OF Β-D-MANNURONIC ACID (M2000) AS A NOVEL NSAID WITH IMMUNOSUPPRESSIVE PROPERTY ON INSULIN PRODUCTION, BLOOD GLUCOSE, AND INFLAMMATORY MARKERS IN THE EXPERIMENTAL DIABETES MODEL, Third International Congress and Fifteenth Iranian Nutrition Congress, تهران, دانشگاه علوم پزشكي شهيد بهشتي - انجمن تغذيه ايران،انستيتو تحقيقات تغذيه اي و صنايع غذايي كشور،انجمن علمي تغذيه ايران, https://www.civilica.com/Paper-INC15-INC15_082.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Alizadeh, Shahab, 2018)
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Type: Medical University
Paper No.: 6412
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