ANTI-DIABETIC EFFECT OF Β-D-MANNURONIC ACID (M2000) AS A NOVEL NSAID WITH IMMUNOSUPPRESSIVE PROPERTY ON INSULIN PRODUCTION, BLOOD GLUCOSE, AND INFLAMMATORY MARKERS IN THE EXPERIMENTAL DIABETES MODEL

Background and Aim: glucose, insulin production, and inflammatory markers in streptozotocin-induced diabetic rats.Methods: Our data showed that the final fasting serum glucose level was significantly lower in the M2000-treated group compared to the diabetic control group (p<.05). In addition, the final fasting serum insulin level significantly increased in the M2000-treated group compared to the diabetic control group (p<.05). Our finding revealed that the serum level of hs-CRP and IL-6 decreased significantly in the M2000-treated group compared to the diabetic control group (p<.05). This study showed that M2000, as a new NSAID, was able to decrease serum glucose levels and increase serum insulin levels and this drug could significantly decrease the inflammatory markers in the M2000-treated group.Conclusion: Collectively, treatment with M2000 might be recommended reducing the severity of diabetes-induced inflammatory symptoms.

Keywords:

M2000 , NSAID , blood glucose , insulin , inflammatory markers