EFFICACY OF COENZYME Q10 FOR THE PREVENTION OF MIGRAINE IN WOMEN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
INC15_144
تاریخ نمایه سازی: 30 دی 1397
Abstract:
Background and Aim: Coenzyme Q10 (CoQ10), as a supplement with a special role in mitochondrial electron transport chain, has been suggested to have prophylactic effect on migraine attacks. The aim of this randomized, doubleblind, placebo-controlled trial was to evaluate the effects of CoQ10 supplementation in the prevention of migraine in conjunction with routine care Methods: Eighty-four women with episodic migraine based on International Classification of Headache Disorder II were randomly allocated in to two groups to receive either 400 mg/day CoQ10 or placebo beside usual prophylactic drugs. Frequency, severity and duration of attacks and headache disability based on migraine specific questionnaires (Headache Impact Test, Migraine Specific Quality of Life and Migraine Disability Assessment) were assessed at the baseline, after 6 and 12 weeks.Results: Seventy-seven of 84 patients completed the study. The results showed significant effect of CoQ10 supplementation on frequency, severity and duration of attacks (All P < 0.001). The percent changes for frequency, severity and duration of attacks in CoQ10 compared to placebo group were 56.7 vs. 41.9, 46.6 vs. 30.1 and 60.0 vs. 37.8 respectively. The number-needed-to-treat for at least 50% reduction in migraine frequency, severity and duration were 4.5, 4.4 and 3.6 respectively. CoQ10 group also had better scores in migraine specific questionnaires at the end of the study compared to control group (All P < 0.001). There were no side-effects noted during the studyConclusion: We concluded that CoQ10 supplementation provided in addition to current migraine prophylactic agents, is well tolerated and seems to be efficacious over time
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Authors
Monir Dahri
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
Mazyar Hashemilar
Department of Neurology, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Asghari-Jafarabadi
Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences,Tabriz, Iran
Ali Tarighat-Esfanjani
Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences,Tabriz, Iran