ASSOCIATION OF BODY MASS INDEX AND WAIST CIRCUMFERENCE WITH OSTEOCALCIN AND C TERMINAL TELOPEPTIDE IN IRANIAN ELDERLY: RESULTS FROM A CROSS SECTIONAL STUDY

Background and Aim: There is no agreement on the role of obesity as a protection or unfavorable factor on bone. In the present study, the association of body mass index (BMI) and waist circumference (WC) with osteocalcin, C-terminal telopeptide of type 1 collagen (CTX-I), highly sensitive C-reactive protein (hs-CRP), parathormon (PTH) and 25-hydroxyvitamin D (25(OH)D) in elderly people was investigated.Methods: This cross-sectional study was conducted on 178 elderly residents in Tehran, with a mean age of 67.04 (60–83). Serum osteocalcin, hs-CRP, 25(OH) D, PTH and urine CTX-I were measured for all participants. Waist circumference, weight and height were measured and BMI was calculated. Linear regression and Pearson correlation were performed to evaluate the relation of BMI and waist circumference with other variables.Results: A significant inverse association was found between BMI with osteocalcin ( = 0.171, p = 0.027) after control for covariates. In addition, there were a significant relation of BMI and WC with hs-CRP ( = 0.246, p = 0.002 and = 0.219, p = 0.006, respectively) and PTH ( = 0.1169, p = 0.040 and = 0.200, p = 0.018), respectively. The present study did not show a significant relation of BMI and WC with urine CTX-I even after adjustment for potential confounders ( = 0.143, p = 0.065 and = 0.104, p = 0.183, respectively).Conclusion: The present study has concluded that obesity is an undesirable factor for bone metabolism by reducing serum osteocalcin and by increasing hs-CRP and PTH which contribute to bone resorption.