A SURVEY ON CLINICAL EFFECTIVENESS OF ORLISTAT COMPARED TO SIBUTRAMINE, LORCASERIN, METFORMIN AND PLACEBO ON WEIGHT LOSS IN OBESE PEOPLE: A NETWORK META-ANALYSIS

Background and Aim: No study compared the effectiveness of medicine sibutramine, orlistat, lorcaserin, and metformin on weight loss in obese individuals. Therefore, the aim of this study was to evaluate the efficacy of Orlistat, Sibutramine, lorcaserin and Metformin on weight loss in obese people.Methods: The databases of Pabmad, Scopus, Google Scholar and Cochran were searched up to November 2016. The pairwise method was used to compare the difference between the mean weight loss for medications in two direct methods (comparison of medications with the control group) and non-direct (Compare medications together).Results: The present study performed on 36 clinical studies with a population of 3672. Results showed that sibutramine (-4.97 kg; -6.70 to -3.23), metformin (-4.45 kg; -9.27 to 0.38), orlistat (-2.37 kg; -3.45 to -1.30), lorcaserin (-2.36 kg; -4. 58 to -0.15), respectively, had the most effect on weight loss compared with the placebo group. In addition, Orlistat compared to lorcaserin (-0.01 kg; -2.47 to 2.45) resulted in more weight loss, but compared to metformin (2.07 kg; -2.78 to 7.02) and sibutramine (0.52 kg; -4.46 to 5.50) lead to less weight loss.Conclusion: The present study indicated that Orlistat had a greater effect on weight loss compared with lorcaserin, and had lower effect on weight loss compared with Sibutramine and Metformin.

Keywords:

Sibutramine , Orlistat , lorcaserin , Metformin , Weight Loss