METABOLICALLY HEALTHY/UNHEALTHY COMPONENTS MAY MODIFY BONE MINERAL DENSITY IN OBESE PEOPLE

Background and Aim: Link between obesity and bone health is controversial. It seems that maybe the difference in metabolic status leads to this difference. We studied relation between metabolically healthy/unhealthy Components with bone mineral density. Results showed MUHO phenotype have better bone status at hip site than MHO. Also, component metabolic can effect on BMD in different sites. This cross-sectional study aimed to comparison total BMD and L-L4 BMD in MHO and MUHO base on Karelis criteria.Methods: We enrolled 272 Iranian obese women and men (BMI ≥30). According to Karelis criteria, the participants were grouped base to MHO and MUHO. The body composition and BMD was assessed for all cases. Serum HDL –C, LDL –C, total Chol, TG, FBS, HOMA –IR, hs-CRP levels were quantified by ELISA method.Results: Our results demonstrate MUHO phenotype have high total BMD more than MHO (P=0.01, CI=0.12 to 0.21). Also, the results of logistic regression analysis showed, MUHO have strongly associated with total BMD (β=-0.42, CI=-0.31 to -0.04, P =0.009), but did not affected L2-L4 BMD (β=-0.09, CI=-0.14 to 0.08, P = 0.578), this represents that there was discordance in MUHO subjects. Our evidence implicated that HOMA-IR, high level serum TG, hs-CRP and low level serum HDL had mediatory effect on relationship between obesity and high BMD at hip region in MUHO subjects (P < 0.05). Conclusion: Present evidence indicates that, could be a novel link novel between difference in MUH phenotype and MH phenotype with bone status. Also, component metabolic can effect on BMD in different sites.

Keywords:

Bone mineral density , metabolically healthy obesity , metabolically unhealthy obesity , Karelis criteria , total BMD , L2-L4 BMD