PROTECTIVE EFFECTS OF SPIRULINA PLATENSIS AND HONEY ON ACETIC ACID-INDUCED ULCERATIVE COLITIS IN RATS
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
View: 424
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
INC15_515
تاریخ نمایه سازی: 30 دی 1397
Abstract:
Background and Aim: In this study, we examined and compared the protective effects of SP and honey on ulcerative colitis induced by acetic acid (AA) in rats. Methods: A total of 40 male rats were allocated into 5 groups (n=8) and received pretreatment for 32 consecutive days. Group 1 (control) was administered normal saline, group 2 (AA-colitis group) received normal saline plus AA, group 3 received 1 ml of honey/day, group 4 received 1 ml of honey/day plus 1 g/kg of SP, and group 5 was administered 1 g/kg of SP. Colitis was induced on the 30th day in groups 2 to 5. On day 32, clinical activity was determined, and anaesthetized animals were sacrificed. Serum interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α), glutathione peroxidase (GPx), reduced glutathione (GSH), total antioxidant capacity (TAC), superoxide dismutase (SOD), myeloperoxidase (MPO) in colonic tissues, prostaglandin E2 (PGE2), malondialdehyde (MDA), nitric oxide (NO), and colonic weight/length ratio were determined. In addition, histopathological changes of the colon were observed microscopically. Results: Pretreatment with honey, SP, and combination regimen significantly attenuated IL-6, TNF- , IL-1 , MPO, PGE2, NO, and MDA levels and increased SOD, GSH, GPx, and TAC levels. Conclusion: Honey and SP may be favorable foods in preventing oxidative stress and inflammatory diseases such as ulcerative colitis.
Keywords:
Authors
Nadia Rezaei
School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Hassan Eftekhari
School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Nader Tanideh
Stem cells technology research center Shiraz University of Medical Sciences, Shiraz, Iran
Maral Mokhtari
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran