Role of personalized medicine to customized risk evaluation ,treatment and surveillance in gastric cancer

Role of personalized medicine to customized risk evaluation ,treatment and surveillance in gastric cancer Personalized medicine is used to learn about a person’s genetic makeup and how their tumor grows.Using this data,physicians hope to find prevention,screening and treatment strategies that may be more effective.By performing genetic tests on the cancer cells and on normal cells ,doctors can customized treatment to each patient with fewer side effects. Gastric cancer is the most common cancer in male population in Iran with high mortality rate.Criteria for risk evaluation of gastric cancer is based on personal and family history of gastric and breast cancer.Most gastric cancers are sporadic ,but 5-10% have a familial component and 3-5%are associated with an inherited cancer predisposition such as hereditary diffuse gastric cancer,lynch syndrome,juvenile polyposis syndrome,peutz-jeghers syndrome and familial adenomatosis polyposis. Treatment protocols is variable according to stage,performance status, comorbidities and genetic profiles.surveillance recommendations based on genetic factors such as CDH1 mutation carriers,Lynch syndrome and… . In all aspects it seams that personalized medicine play an important role with more effective outcomes.

Keywords:

gastric cancer treatment