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Determination the level of PTEN and CDKN1C/p57kip2 Tumor Suppressor Gene expression in tumor tissue of patients with gastric cancer compared with its peripheral healthy tissues

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Year: 2016
COI code: IPMCMED01_019
Paper Language: English

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Authors Determination the level of PTEN and CDKN1C/p57kip2 Tumor Suppressor Gene expression in tumor tissue of patients with gastric cancer compared with its peripheral healthy tissues

Sareh Sohrabi - Department of Molecular Medicine and Genetics, Molecular Medicine Research Center
Massoud Saidijam - Department of Molecular Medicine and Genetics, Molecular Medicine Research Center

Abstract:

Background: Gastric cancer is the third most common cause of cancer-related death in the world. In the Islamic Republic of Iran, stomach malignancy have the highest incidence and mortality rates of cancer. Unfortunately gastric cancer remains difficult to cure, because the most patients present with advanced disease so early diagnosis and treatment leads to improved survival. Genetic and epigenetic changes in tumor suppressor genes (TSGs) frequently occur in human cancers. Some studies indicated that loss of TSGs is a key event in gastric carcinoma. Many TSG candidates have been studied, but based on epigenetic alteration each population is valuable to evaluate. So this study investigated the expression rate of PTEN and CDKN1C in a small available population in Iran. Methods: 64 gastric samples (32 tumoral gastric tissues and 32 healthy adjacent tissues) were collected from patients referred to Imam Khomeini Hospital Cancer Institute during 2008-2011. Total RNA was extracted, cDNA synthesized, then expression level of PTEN and CDKN1C was detected by Real time-PCR. Results: Our results displayed PTEN and CDKN1C expression significantly decreased in cancerous tissues compared to healthy adjacent tissues (PConclusion: A significant expression decrease of both tumor suppressor genes (PTEN and CDKN1C) in tumoral tissues compared with healthy adjacent tissues suggest that these genes have important role in gastric cancer incidence and future researches may reveal their advantage in treatment and diagnosis.

Keywords:

Stomach Neoplasms, Gene Expression, PTEN, Cyclin-Dependent Kinase Inhibitor p57, Real-time PCR

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COI code: IPMCMED01_019

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Sohrabi, Sareh & Massoud Saidijam, 2016, Determination the level of PTEN and CDKN1C/p57kip2 Tumor Suppressor Gene expression in tumor tissue of patients with gastric cancer compared with its peripheral healthy tissues, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_019.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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