CIVILICA We Respect the Science
Publisher of Iranian Journals and Conference Proceedings
Paper
title

Investigation of the CYLD promoter methylation pattern in gastric cancer

Credit to Download: 0 | Page Numbers 1 | Abstract Views: 126
Year: 2016
COI code: IPMCMED01_026
Paper Language: English

How to Download This Paper

For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.

Authors Investigation of the CYLD promoter methylation pattern in gastric cancer

  Elham Ghadami - Department of Surgery, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
  Novin Nikbakhsh - Department of Surgery, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
  Mohadese Kosari - Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
  Maryam Pilehchian - Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

Abstract:

Intoduction: Gastric cancer is one of the most common malignancies and cause of cancer death in the world. DNA methylation plays an important role in development and prognosis of gastric cancer. Hypermethylation of tumor suppressor genes is involved in initiation and progression of many types of cancer. Tumor suppressor gene CYLD negatively regulates various signaling pathways including Wnt, Shh, and Notch. In this study we evaluated promoter methylation pattern of CYLD gene in gastric cancer patients.Materials and methods: Tumoral tissues of thirty gastric cancer patients and their adjacent non-tumoral counterparts were studied. DNA extraction and bisulfite treatment followed by sequencing of PCR products were performed.Results: Promoter hypermethylation of the CYLD gene was found in 14(46%) of the 30 tumoral tissues. Also, 6(20%) hemi-methylated tumor margin tissues were observed.Discussion: CYLD promoter hypermethylation can be associated with gastric cancer risk. Because of DNA methylation is a reversible process, it may be a new target to prevent progression of gastric cancer.

Keywords:

Gastric cancer, CYLD, Promoter methylation

Perma Link

https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_026.html
COI code: IPMCMED01_026

how to cite to this paper:

If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Ghadami, Elham; Novin Nikbakhsh; Mohadese Kosari & Maryam Pilehchian, 2016, Investigation of the CYLD promoter methylation pattern in gastric cancer, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_026.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Ghadami, Elham; Novin Nikbakhsh; Mohadese Kosari & Maryam Pilehchian, 2016)
Second and more: (Ghadami; Nikbakhsh; Kosari & Pilehchian, 2016)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)

Scientometrics

The University/Research Center Information:
Type: Medical University
Paper No.: 755
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.

Research Info Management

Export Citation info of this paper to research management softwares

New Related Papers

Iran Scientific Advertisment Netword

Share this paper

WHAT IS COI?

COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.