Published in: First Personal Medical Congress
COI code: IPMCMED01_026
Paper Language: English
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Authors Investigation of the CYLD promoter methylation pattern in gastric cancerElham Ghadami - Department of Surgery, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
Novin Nikbakhsh - Department of Surgery, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
Mohadese Kosari - Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Maryam Pilehchian - Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Abstract:Intoduction: Gastric cancer is one of the most common malignancies and cause of cancer death in the world. DNA methylation plays an important role in development and prognosis of gastric cancer. Hypermethylation of tumor suppressor genes is involved in initiation and progression of many types of cancer. Tumor suppressor gene CYLD negatively regulates various signaling pathways including Wnt, Shh, and Notch. In this study we evaluated promoter methylation pattern of CYLD gene in gastric cancer patients.Materials and methods: Tumoral tissues of thirty gastric cancer patients and their adjacent non-tumoral counterparts were studied. DNA extraction and bisulfite treatment followed by sequencing of PCR products were performed.Results: Promoter hypermethylation of the CYLD gene was found in 14(46%) of the 30 tumoral tissues. Also, 6(20%) hemi-methylated tumor margin tissues were observed.Discussion: CYLD promoter hypermethylation can be associated with gastric cancer risk. Because of DNA methylation is a reversible process, it may be a new target to prevent progression of gastric cancer.
Keywords:Gastric cancer, CYLD, Promoter methylation
COI code: IPMCMED01_026
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Ghadami, Elham; Novin Nikbakhsh; Mohadese Kosari & Maryam Pilehchian, 2016, Investigation of the CYLD promoter methylation pattern in gastric cancer, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_026.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Ghadami, Elham; Novin Nikbakhsh; Mohadese Kosari & Maryam Pilehchian, 2016)
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The University/Research Center Information:
Type: Medical University
Paper No.: 755
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