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Analysis of VEGF Gene Methylation Pattern and Metabolic Syndrome

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Year: 2016
COI code: IPMCMED01_036
Paper Language: English

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Authors Analysis of VEGF Gene Methylation Pattern and Metabolic Syndrome

  Nahid Talebzadeh - Department of Molecular Biology, Ahar Branch, Islamic Azad University, Ahar, Iran
  Saeid Ghorbian - Department of Molecular Biology, Ahar Branch, Islamic Azad University, Ahar, Iran


Introduction: Metabolic syndrome (MS) involved multiple disorders such as diabetes, hypertension and obesity, which were associated considerably with changes in gene expression that are originated through genetic, epigenetic and environmental factors. DNA methylation is a most common epigenetic variation that regulates gene expression in physiologic and pathologic conditions. We aim to assess methylation patterns of promoter regions of vascular endothelial growth factor gene (VEGF), which may be acts a critical role in the pathogenesis of MS. Materials and Methods: In this case-control investigation, we were assessed a total of 100 subjects, which were included 50 of cases diagnosed as MS and 50 in healthy individuals as a control group. Methyl specific polymerase chain reaction (MS –PCR) method was performed to analysis of VEGF gene promoter methylatin patterns. Results: The frequencies of VEGF gene promoter methylation observed in 32% (16/50) and 20% (10/50) of case and control individuals, respectively. Our findings revealed that the frequencies of the gene methylated was not statistically significant difference between two groups (p-value > 0.05). Conclusions: Due to the small sample size suggested that more evidence will be needed to approve the present results, which was not considered the VEGF gene methylation as a predisposed factors in feature of MS.


VEGF, Metabolic syndrome, Methylation, Promoter

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COI code: IPMCMED01_036

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Talebzadeh, Nahid & Saeid Ghorbian, 2016, Analysis of VEGF Gene Methylation Pattern and Metabolic Syndrome, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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The University/Research Center Information:
Type: Azad University
Paper No.: 2274
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