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title

association of single nucleotide polymorphism rs76121131[C> t] in CD44 related with hsa-miR-3929and Gastric cancer

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Year: 2016
COI code: IPMCMED01_050
Paper Language: English

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Authors association of single nucleotide polymorphism rs76121131[C> t] in CD44 related with hsa-miR-3929and Gastric cancer

Samaneh Samani - Division of cellular and Molecular biology,Department of biology, Nour danesh institute of higher education ,Meymeh,Iran
  Mansoureh Azadeh - Department of Biochemistry, Faculty of Basic Science, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran
Pardis Saadatmand - Zist fanavary Novin, Biotechnology Institute, Isfahan, Iran
  Kamran Ghaedi - Division of Cellular and Molecular Biology, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran

Abstract:

Nowadays, treatment can be done with genetic variation. SNPs are the most important biomarkers for personalized medicine.MicroRNAs (miRNAs) participate in diverse biological pathways and may act as oncomir or tumor suppressors, so they could be used as a prognostic biomarker. The aim of our study is to expand current knowledge about molecular function of hsa-miR-3929 and its relatede SNP in gastric cancer cells by using bioinformatics tools.Validated and predicted targets of hsa-miR-3929 were obtained from miRbase and miRwalk databases respectively. miRBase and DAVID databases were used for further analysis. miRNASNP database predicts single nucleotide polymorphism in 3’UTR of a gene (CD44) related to hsa- miR-3929.It is predicted that hsa-miR-3929acts as a critical tumor suppressor micro RNA by inhibiting some important genes in sustained angiogenesis pathway.Our data manifested KEGG signaling pathways pathway in cancer as the most statistical relevant pathways with hsa-miR3929 targetome.According to our data, hsa- miR-3929 and its related SNP may be involved in gastriccancer prognosis by altering regulation of angiogenesis and some vital signaling pathways mRNAs. To sum up, C allele in this location can have prognostic value for angiogenesis and metastasis phenotypes in patients with gastric carcinoma.

Keywords:

gastric cancer, hsa-miR-3929, SNP,KEGG

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COI code: IPMCMED01_050

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Samani, Samaneh; Mansoureh Azadeh; Pardis Saadatmand & Kamran Ghaedi, 2016, association of single nucleotide polymorphism rs76121131[C> t] in CD44 related with hsa-miR-3929and Gastric cancer, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_050.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Samani, Samaneh; Mansoureh Azadeh; Pardis Saadatmand & Kamran Ghaedi, 2016)
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