Study of association between hsa-miR-940 targetom signaling pathways it is related SNP(rs3859431)functionally with the incident of LHON

Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

IPMCMED01_054

تاریخ نمایه سازی: 23 آذر 1397

Abstract:

LHON is one of the usual disorder, optic neuropathy that makes a loss of central vision and always is associated with mitochondrial point mutation. the first cells lost are Retinal ganglion and they are so sensitive to incomplete ATP and oxidation. the genetic of LHON is connected to Mt genetic.Genetic in this case is one of the important reasons, more than the environment. In LHON often lost vision is part of clinical appearance and the patients suffer from Neurological disorder. the Men are more exposed. Abnormal function of Mt is dependent on Energetic disorder, that it can spoil nerves pathway and Retinal cells.Nowadays, treatment can be done with genetic variation. SNPs are the most important biomarkers for personalized medicine.MicroRNAs (miRNAs) participate in diverse biological pathways and may act as oncomir or tumor suppressors,and Operating regulation so they could be used as a prognostic biomarker. The aim of our study is to expand current knowledge about molecular function of hsa-miR-940and its relatede SNP in LHON by using bioinformatics tools.Validated and predicted targets of hsa-miR-940were obtained from miRbase and miRwalk databases respectively. miRBase and DAVID databases were used for further analysis. miRNASNP database predicts single nucleotide polymorphism in 3UTR of a gene (CRX) related to hsa- miR-940. Our data manifested KEGG and DAVID signaling pathways Acxon Guideance Pathway1 2and Prion Diseaseas , Glioma3 4the most statistical relevant pathways with hsa-miR940 targetome. To sum up, the genotyping of the C allele in this location(23808) in the CRX gene can have prognostic of LHON.

Authors

Samaneh Samani

Division of cellular and Molecular biology,Department of biology, Nour danesh institute of higher education ,Meymeh,Iran

Pardis Saadatmand

Zist fanavary Novin, Biotechnology Institute, Isfahan, Iran

Negin Hoghoughi

Zist fanavary Novin, Biotechnology Institute, Isfahan, Iran

Mansoureh Azadeh

Department of Biochemistry, Faculty of Basic Science, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran