Analysis of the CYP3A4 gene variant (rs2740574) in an Iranian Population: Pilot base study

Various studies revealed that, CYP3A4*1B, as a variant allele of CYP3A4 gene, hasvariations in populations with different ethnic background. In this pilot research work, westudied 183 healthy non consanguinity men of an Iranian origin for this genetic variation. Weapplied RFLP-PCR technique for this research study. In contrast with other researches, in Asiancountry (such as China and Japan with 0% allele frequency) our study showed that frequency ofthis allele in Iranian men among an Asian continent is 3%. This finding is an important attemptin pharmacogenetics research endeavor.

Keywords:

CYP450 , CYP3A4 , CYP3A4*1B , genetic variant