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Analysis of the CYP3A4 gene variant (rs2740574) in an Iranian Population: Pilot base study

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Year: 2016
COI code: IPMCMED01_056
Paper Language: English

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Authors Analysis of the CYP3A4 gene variant (rs2740574) in an Iranian Population: Pilot base study

Arezu Karimpur Zahmatkesh - Shahid Dr Beheshti Medical Sciences University, Faculty of medicine, Medical Genetics Department
Abolfazl Movafagh - Shahid Dr Beheshti Medical Sciences University, Faculty of medicine, Medical Genetics Department

Abstract:

Various studies revealed that, CYP3A4*1B, as a variant allele of CYP3A4 gene, hasvariations in populations with different ethnic background. In this pilot research work, westudied 183 healthy non consanguinity men of an Iranian origin for this genetic variation. Weapplied RFLP-PCR technique for this research study. In contrast with other researches, in Asiancountry (such as China and Japan with 0% allele frequency) our study showed that frequency ofthis allele in Iranian men among an Asian continent is 3%. This finding is an important attemptin pharmacogenetics research endeavor.

Keywords:

CYP450, CYP3A4, CYP3A4*1B, genetic variant

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COI code: IPMCMED01_056

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Karimpur Zahmatkesh, Arezu & Abolfazl Movafagh, 2016, Analysis of the CYP3A4 gene variant (rs2740574) in an Iranian Population: Pilot base study, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_056.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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